I3C Vegetables and Breast Cancer
Indole 3 Carbinol Reduces Cancer Risk
Indole 3 Carbinol, I3C, is isolated from cruciferous vegetables. This phytochemical changes estradiol, a strong estrogen associated with breast cancer, to estratriol, a weaker estrogen. When I3C occupies the estrogen receptor, it blocks estradiol and it’s ability to signal cancer cells to grow. It effectively stops cancer growth up to 64% and promotes cancer cell destruction. (1991 research)
By 1997, the Strang Cancer Research Lab (Rockefeller University) discovery led to subsequent research at UC Berkeley. I3C inhibited human breast cancer cells growing in a culture by 90%, inhibiting MCF7 cancer cells. (Tamoxifen=60%)
There is more research at NYU that indicates I3C changes the metabolism of estrogen to inhibit the biologically active 16alpha0HE, which enhances breast cancer cell growth. In so doing, I3C increases 2-0HE, which is metabolically inactive and blocks the estrogen metabolism that is harmful.
16alpha0HE - 16 alpha-hydroxestrone which is bad
2-0HE - 2 hydroxyestrone which is good
However, women who have a mutated gene, which retards the 2-OHE, do not benefit as much as other women from the I3C. They have an 8 times higher risk of breast cancer.
I3C also helps regulate new cell growth, p21, which restores tumor suppressor p53. I3C inhibits cancer caused by other chemicals and environmental pollutants. Damaged DNA cells were reduced by 91% I3C in studies on rodents exposed to cancer causing chemicals. I3C regulates estrogen, metabolites of estrogen and DNA damage to cells caused by cancer and related drugs.
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